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pentobarbital will lessen the level or influence of buprenorphine, very long-acting injection by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Patients who transfer to buprenorphine very long-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers ought to be monitored to be ce